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J Clin Microbiol. 1976 September; 4(3): 309-311

New assay of protective activity of Rocky Mountain spotted fever vaccines.

R L Anacker, R F Smith, R E Mann and M A Hamilton

ABSTRACT

Areas under the fever curves of guinea pigs inoculated with Rocky Mountain spotted fever vaccine over a restricted dose range and infected with a standardized dose of Rickettsia rickettsii varied linearly with log10 dose of vaccine. A calculator was programmed to plot fever curves and calculate the vaccine dose that reduced the fever of infected animals by 50%.

J Clin Microbiol. 1976 September; 4(3): 309-311






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Antimicrob. Agents Chemother. Clin. Microbiol. Rev.
Clin. Vaccine Immunol. ALL ASM JOURNALS

Copyright © 1976 by the American Society for Microbiology. All rights reserved.