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Journal of Clinical Microbiology, January 2002, p. 10-15, Vol. 40, No. 1
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.1.10-15.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Change of Major Genotype of Enterovirus 71 in Outbreaks of Hand-Foot-and-Mouth Disease in Taiwan between 1998 and 2000

Jen-Ren Wang,1,2,3* Yen-Chang Tuan,2 Huey-Pin Tsai,3 Jing-Jou Yan,3,4 Ching-Chuan Liu,3,5 and Ih-Jen Su2,3,4,{dagger}

Institute of Molecular Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan,2 Departments of Medical Technology, College of Medicine, National Cheng Kung University, Tainan, Taiwan,1 Pathology, College of Medicine, National Cheng Kung University, Tainan, Taiwan,4 Pediatrics, College of Medicine, National Cheng Kung University, Tainan, Taiwan,5 National Health Research Institutes Tainan Virology Laboratory for Diagnosis and Research, Department of Pathology, National Cheng Kung University Hospital, Tainan, Taiwan3

Received 30 April 2001/ Returned for modification 23 August 2001/ Accepted 9 October 2001

Two outbreaks of hand-foot-and-mouth disease (HFMD) occurred in Taiwan between 1998 and 2000. Enteroviruses were isolated from a total of 1,892 patients in this laboratory during this period. Of the virus isolates, enterovirus 71 (EV71) was diagnosed in 44.4% of the patients (132 of 297) in 1998, 2% (13 of 646) in 1999, and 20.5% (195 of 949) in 2000. Genetic analyses of the 5'-untranslated and VP1 regions of EV71 isolates by reverse transcription-PCR and sequencing were performed to understand the diversity of EV71 in these outbreaks of HFMD. Most EV71 isolates from the 1998 epidemic belonged to genotype C, while only one-tenth of the isolates were genotype B. Interestingly, all EV71 isolates tested from 1999 to 2000 belonged to genotype B. This study indicated that two genogroups of EV71 capable of inducing severe clinical illness have been circulating in Taiwan. Furthermore, the predominant EV71 genotypes responsible for each of the two major HFMD outbreaks within the 3-year period in Taiwan were different.

* Corresponding author. Mailing address: Department of Medical Technology, College of Medicine, National Cheng Kung University, One University Rd., Tainan 701, Taiwan. Phone and fax: 886-6-2760695. E-mail: jrwang{at}mail.ncku.edu.tw.

{dagger} Present address: Department of Pathology, National Taiwan University, Taipei, Taiwan.

Journal of Clinical Microbiology, January 2002, p. 10-15, Vol. 40, No. 1
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.1.10-15.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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