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Journal of Clinical Microbiology, January 2002, p. 256-258, Vol. 40, No. 1
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.1.256-258.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Molecular Typing of Treponema pallidum in South Africa: Cross-Sectional Studies

A. Pillay,1* H. Liu,1 S. Ebrahim,2 C. Y. Chen,1 W. Lai,1 G. Fehler,3,4 R. C. Ballard,1 B. Steiner,1 A. W. Sturm,2 and S. A. Morse1

Centers for Disease Control and Prevention, Atlanta, Georgia,1 Department of Medical Microbiology, Africa Centre for Population Studies and Reproductive Health, Medical Research Council Genital Ulcer Disease Research Unit, University of Natal Medical School, Durban, South Africa,2 National Reference Centre for Sexually Transmitted Diseases, Department of Clinical Microbiology and Infectious Diseases, University of Witwatersrand,3 South African Institute of Medical Research, Johannesburg, South Africa4

Received 17 August 2001/ Returned for modification 9 September 2001/ Accepted 17 October 2001

We evaluated a molecular subtyping system for Treponema pallidum for its ability to differentiate between strains obtained from male patients with primary syphilis in South Africa. Of 201 T. pallidum-positive specimens, 161 were typeable, revealing 35 subtypes. The unique subtypes identified in Durban, Cape Town, and Carletonville and the total number of subtypes suggested that the strain population was very diverse and varied geographically.

* Corresponding author. Mailing address: Centers for Disease Control and Prevention, Division of AIDS, STD, and TB Laboratory Research, 1600 Clifton Rd., MS-G39, Atlanta, GA 30333. Phone: (404) 639-2140. Fax: (404) 639-3976. E-mail: Apillay{at}cdc.gov.

Journal of Clinical Microbiology, January 2002, p. 256-258, Vol. 40, No. 1
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.1.256-258.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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