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Journal of Clinical Microbiology, January 2002, p. 259-261, Vol. 40, No. 1
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.1.259-261.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Assessment of Clarithromycin-Resistant Helicobacter pylori among Patients in Shanghai and Guangzhou, China, by Primer-Mismatch PCR

Zhi-Jun Pan,1,{dagger} Wan-Wen Su,2 Guido N. J. Tytgat,3 Jacob Dankert,1 and Arie van der Ende1*

Department of Medical Microbiology,1 Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri,2 Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands3

Received 24 April 2001/ Returned for modification 13 July 2001/ Accepted 9 October 2001

Of 96 Helicobacter pylori isolates from patients in Shanghai and Guangzhou, China, 5 had the A2143G 23S rRNA mutation as determined by primer-mismatch PCR and were resistant to clarithromycin by the E-test. The remaining isolates were primer-mismatch PCR negative and susceptible to clarithromycin. The conclusion is that the prevalence of clarithromycin-resistant H. pylori isolates among these Chinese patients is 5%.

* Corresponding author. Mailing address: Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, P.O. Box 22700, 1100 DE Amsterdam, The Netherlands. Phone: 31-20-5664862. Fax: 31-20-6979271. E-mail: a.vanderende{at}amc.uva.nl.

{dagger} Present address: Department of Internal Medicine, Washington University School of Medicine, St. Louis, Mo.

Journal of Clinical Microbiology, January 2002, p. 259-261, Vol. 40, No. 1
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.1.259-261.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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