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Journal of Clinical Microbiology, January 2002, p. 262-264, Vol. 40, No. 1
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.1.262-264.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Accurate, Noninvasive Detection of Helicobacter pylori DNA from Stool Samples: Potential Usefulness for Monitoring Treatment

Applied Research Group, Exact Sciences Corporation, Maynard, Massachusetts 01754,¹ Division of Gastroenterology/Hepatology,² Department of Pathology, University of Virginia Health System, Charlottesville, Virginia 22908³

Received 12 July 2001/ Returned for modification 20 August 2001/ Accepted 5 October 2001

A novel DNA assay demonstrating sensitive and accurate detection of Helicobacter pylori from stool samples is reported. Moreover, in three individuals tested for therapeutic response, the assay showed the disappearance of H. pylori DNA during treatment. Thus, this noninvasive molecular biology-based assay has the potential to be a powerful diagnostic tool given its ability to specifically identify H. pylori DNA.

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