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Journal of Clinical Microbiology, January 2002, p. 309-310, Vol. 40, No. 1
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.1.309-310.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Primary Meningoencephalitis by Naegleria fowleri: First Reported Case from Mangalore, South India

Department of Microbiology, Kasturba Medical College, Mangalore, Karnataka, 575001, India¹

Received 11 June 2001/ Returned for modification 31 July 2001/ Accepted 2 October 2001

A fatal case of primary amebic meningoencephalitis (PAM) in a 5-month-old infant is described. The disease may have been contracted during bathing. The source of water was from an artificial well. The clinical presentation, the isolation of the ameba from the cerebrospinal fluid, the poor response to amphotericin B, and the ultimate fatal outcome are all consistent with the diagnosis of PAM. On the basis of its ability to grow at temperatures above 30°C, the morphology of the trophozoite, and the presence of flagellate forms, the ameba was identified as Naegleria fowleri. Pathogenic N. fowleri amebae were recovered from samples of water from the well. To our knowledge this case represents the second case of PAM in an infant in the absence of the history of swimming.

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