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Association of the prtF1 Gene (Encoding Fibronectin-Binding Protein F1) and the sic Gene (Encoding the Streptococcal Inhibitor of Complement) with emm Types of Group A Streptococci Isolated from Japanese Children with Pharyngitis

Department of Pediatrics, Hokkaido University School of Medicine, Sapporo,¹ School of Nursing, Faculty of Medicine, Toho University,² Department of Infectious Diseases, Mitsubishi Kagaku Bio-Clinical Laboratory, Tokyo, Japan³

Received 3 May 2002/ Returned for modification 18 June 2002/ Accepted 17 July 2002

A total of 66 clinical isolates of group A streptococci (GAS) were obtained from 66 Japanese children with pharyngitis. The prtF1 gene (encoding fibronectin-binding protein F1) and the sic gene (encoding the streptococcal inhibitor of complement) were present in 51 (77.3%) and 48 (72.7%) of the 66 isolates, respectively. These results indicated that a high prevalence of two virulence genes, prtF1 and sic, is characteristic of GAS in Japan.

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