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Journal of Clinical Microbiology, October 2002, p. 3863-3864, Vol. 40, No. 10
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.10.3863-3864.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Stability of Human Immunodeficiency Virus Type 1 RNA in Cerebrospinal Fluid Determined with the AMPLICOR HIV-1 MONITOR Test, Version 1.5 (Ultrasensitive)

Elyse J. Singer,1* H. Aaron Aronow,2 Shing-Yi Lee,3 Charles H. Hinkin,4 and Tadd Lazarus5

Department of Neurology, University of California at Los Angeles School of Medicine, and Department of Neurology, Greater Los Angeles Veteran's Affairs Healthcare System,1 Departments of Neurology and Internal Medicine, University of Southern California Keck School of Medicine, and Department of Research, AIDS Healthcare Foundation,2 Molecular Biology, Consolidated Laboratory,3 Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles School of Medicine, and Psychology Service, Greater Los Angeles Veterans Affairs Healthcare System, Los Angeles, California,4 Department of Internal Medicine, New York Medical College, and Roche Diagnostics Corporation, Indianapolis, Indiana5

Received 8 January 2002/ Returned for modification 21 March 2002/ Accepted 28 June 2002

We evaluated the effects of time, temperature, freezing, and thawing on the cerebrospinal fluid viral load by using the Roche AMPLICOR HIV-1 MONITOR test, version 1.5 (ultrasensitive). While a statistically significant decrease from the baseline was observed at 24 h, but not at 6 or 12 h, and with one freeze-thaw cycle, all changes were within the range of intra-assay variability.

* Corresponding author. Mailing address: 11645 Wilshire Blvd., Suite 770, Los Angeles, CA 90025. Phone: (310) 473-5500. Fax: (310) 473-7772. E-mail: esinger{at}ucla.edu.

Journal of Clinical Microbiology, October 2002, p. 3863-3864, Vol. 40, No. 10
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.10.3863-3864.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.





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