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Journal of Clinical Microbiology, November 2002, p. 4367-4371, Vol. 40, No. 11
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.11.4367-4371.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Immune Responses of Sheep to Quadrivalent Double Emulsion Foot-and-Mouth Disease Vaccines: Rate of Development of Immunity and Variations among Other Ruminants

Prasanna K. Patil,1,2 Jagadeesh Bayry,1,3* Chitimalla Ramakrishna,1 Basavesh Hugar,4 Laxmi D. Misra,1 Krishnamsetty Prabhudas,1 and C. Natarajan1

Indian Veterinary Research Institute, Bangalore 560 024,1 Veterinary Hospital, Shikaripura, Karnataka,2 Veterinary Hospital, Kumsi, Shimoga, India,4 INSERM U430, Hôpital Broussais, Paris 75014, France3

Received 16 August 2001/ Returned for modification 21 December 2001/ Accepted 16 August 2002

Despite representing the majority of the world's foot-and-mouth disease (FMD)-susceptible livestock, sheep and goats have generally been neglected with regard to their epidemiological role in the spread of FMD. In the present investigations, FMD virus quadrivalent double emulsion (Montanide ISA 206) vaccines were tested in sheep. The oil adjuvant elicited a better immune response at any time than did aluminum hydroxide gel vaccine, and the response developed quicker. The animals maintained their neutralizing antibody titers at >3 log10 for the duration of the trial (90 days). Sheep were found to be late responders to serotypes A, C, and Asia-1; a clear upward shift in titer was observed at 60 days postvaccination. However, development of the immune response to serotype O in sheep was superior to that in cattle and goats.

* Corresponding author. Mailing address: INSERM U430 Immunopathologie Humaine, Hôpital Broussais, 96, rue Didot, 75014 Paris, France. Phone: 33-1-43 95 95 89. Fax: 33-1-45 45 90 59. E-mail: jbayry{at}yahoo.com.

Journal of Clinical Microbiology, November 2002, p. 4367-4371, Vol. 40, No. 11
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.11.4367-4371.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.





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Antimicrob. Agents Chemother. Clin. Microbiol. Rev.
Clin. Vaccine Immunol. ALL ASM JOURNALS

Copyright © 2002 by the American Society for Microbiology. All rights reserved.