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Journal of Clinical Microbiology, December 2002, p. 4741-4743, Vol. 40, No. 12
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.12.4741-4743.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Endemic Carbapenem Resistance Associated with OXA-40 Carbapenemase among Acinetobacter baumannii Isolates from a Hospital in Northern Spain

F. Lopez-Otsoa,1 L. Gallego,1 K. J. Towner,2* L. Tysall,3 N. Woodford,3 and D. M. Livermore3

Departamento de Immunologia, Microbiologia y Parasitologia, Facultad de Medicina y Odontologia, Universidad del Pais Vasco, 48080 Bilbao, Spain,1 Molecular Diagnostics & Typing Unit, Public Health Laboratory, University Hospital, Queen's Medical Centre, Nottingham NG7 2UH,2 Antibiotic Resistance Monitoring and Reference Laboratory, Central Public Health Laboratory, London NW9 5HT, United Kingdom3

Received 8 July 2002/ Returned for modification 17 August 2002/ Accepted 29 August 2002

Eighty-two carbapenem-resistant isolates of Acinetobacter baumannii from a single hospital in Bilbao were typed into two major clusters and several subclusters. Disk synergy tests and PCR indicated the production of a zinc-independent OXA-class carbapenemase. Sequencing identified this enzyme, OXA-40, as a variant of the OXA-24-OXA-25-OXA-26 cluster.

* Corresponding author. Mailing address: Molecular Diagnostics & Typing Unit, Public Health Laboratory, University Hospital, Queen's Medical Centre, Nottingham NG7 2UH, United Kingdom. Phone: 44-115-9709163. Fax: 44-115-9422190. E-mail: ktowner{at}trent.phls.nhs.uk.

Journal of Clinical Microbiology, December 2002, p. 4741-4743, Vol. 40, No. 12
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.12.4741-4743.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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