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Journal of Clinical Microbiology, December 2002, p. 4753-4756, Vol. 40, No. 12
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.12.4753-4756.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

New Serological Assay for Detection of Putative Helicobacter pylori Virulence Factors

Chang-Young Park,1,2 Yong-Kyun Cho,2 Tadashi Kodama,3 Hala M. T. El-Zimaity,1 Michael S. Osato,1 David Y. Graham,1 and Yoshio Yamaoka1*

Department of Medicine, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas,1 Department of Internal Medicine, Kangbuk Samsung Hospital, School of Medicine, Sunkyunkwan University, Seoul, Korea,2 Third Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan3

Received 13 June 2002/ Returned for modification 5 August 2002/ Accepted 3 September 2002

We evaluated a new immunoblot assay (Helicoblot 2.1) for Helicobacter pylori infection and CagA and VacA status by using serum samples from 222 patients. The test accurately detected H. pylori infection and VacA status, but improvements in the interpretation criteria are required before it can be recommended for determination of CagA status.

* Corresponding author. Mailing address: Veterans Affairs Medical Center (111D), 2002 Holcombe Blvd., Houston, TX 77030. Phone: (713) 794-7234. Fax: (713) 790-1040. E-mail: yyamaoka{at}bcm.tmc.edu.

Journal of Clinical Microbiology, December 2002, p. 4753-4756, Vol. 40, No. 12
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.12.4753-4756.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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Copyright © 2002 by the American Society for Microbiology. All rights reserved.