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Journal of Clinical Microbiology, December 2002, p. 4771-4775, Vol. 40, No. 12
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.12.4771-4775.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Are There Naturally Occurring Pleomorphic Bacteria in the Blood of Healthy Humans?

Richard W. McLaughlin,1 Hojatollah Vali,1 Peter C. K. Lau,2 Roger G. E. Palfree,1 Angela De Ciccio,1 Marc Sirois,3 Darakhshan Ahmad,4 Richard Villemur,5 Marcel Desrosiers,5 and Eddie C. S. Chan1*

Faculties of Dentistry and Medicine, McGill University, Montreal, Quebec H3A 2B4,1 Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec H4P 2R2,2 Departément de Chimie-Biologie, Université du Quebec à Trois-Rivieres, Quebec G9A 5H7,3 INRS-Institut Armand Frappier, Pointe Claire, Quebec H9R 1G6,4 INRS-Institut Armand Frappier, Laval, Quebec H7V 1B7, Canada5

Received 1 February 2002/ Returned for modification 2 June 2002/ Accepted 16 August 2002

Dark-field microscopy of blood from healthy individuals revealed the existence of pleomorphic microorganisms. These bacteria exhibited limited growth and susceptibility to antibiotics and could be detected by fluorescent in situ hybridization and flow cytometry. They were further characterized by analysis of their 16S rRNA and gyrB genes.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, McGill University, 3775 University St., Montreal, Quebec H3A 2B4, Canada. Phone: (514) 398-3916. Fax: (514) 398-7052. E-mail: eddie.chan{at}mcgill.ca.

Journal of Clinical Microbiology, December 2002, p. 4771-4775, Vol. 40, No. 12
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.12.4771-4775.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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