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Journal of Clinical Microbiology, December 2002, p. 4785-4788, Vol. 40, No. 12
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.12.4785-4788.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Molecular Epidemiology of Tuberculosis in a Rural Area of High Prevalence in South India: Implications for Disease Control and Prevention

Sujatha Narayanan,1 Sulochana Das,1 Renu Garg,2 Lalitha Hari,1 Vijay Bhaskara Rao,1 Thomas R. Frieden,2 and P. R. Narayanan1*

Tuberculosis Research Centre, Chennai,the,1 World Health Organization, Stop Tuberculosis Unit, South East Asian Regional Office, New Delhi, India2

Received 28 May 2002/ Returned for modification 9 July 2002/ Accepted 10 September 2002

Molecular and conventional epidemiologic techniques were used to study the mechanisms and risk factors for tuberculosis transmission in a rural area with high prevalence in south India. Restriction fragment length polymorphism analysis with IS6110 and direct repeat probes was performed with 378 Mycobacterium tuberculosis isolates from patients. Forty-one percent of M. tuberculosis isolates harbored a single copy of IS6110. Of 378 patients, 236 had distinct strains; 142 (38%) shared a strain with other patients, indicating recent infection. Older patients, those detected by a house-to-house community survey, and those hospitalized in a sanatorium were more likely to have had a recent infection. These findings suggest that the majority of the tuberculosis cases in south India were due to reactivation; therefore, efforts to control tuberculosis should be sustained.

* Corresponding author. Mailing address: Tuberculosis Research Centre, Mayor V. R. Ramanathan Rd. (Spurtank Rd.), Chetput, Chennai 600 031, India. Phone: 91 (044) 8265425. Fax: 91 (044) 8262137. E-mail: nrparanj{at}md2.vsnl.net.in.

Journal of Clinical Microbiology, December 2002, p. 4785-4788, Vol. 40, No. 12
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.12.4785-4788.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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