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Journal of Clinical Microbiology, December 2002, p. 4797-4799, Vol. 40, No. 12
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.12.4797-4799.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

CASE REPORT

Rotavirus Gastroenteritis and Central Nervous System (CNS) Infection: Characterization of the VP7 and VP4 Genes of Rotavirus Strains Isolated from Paired Fecal and Cerebrospinal Fluid Samples from a Child with CNS Disease

M. Iturriza-Gómara,^1, I. A. Auchterlonie,² W. Zaw,² P. Molyneaux,³ U. Desselberger,¹ and J. Gray^1*

Clinical Microbiology and Public Health Laboratory, Addenbrooke's Hospital, Cambridge,¹ Department of Medical Paediatrics, The Royal Aberdeen Children's Hospital,² Department of Medical Microbiology, Aberdeen Royal Infirmary, Aberdeen, United Kingdom³

Received 9 April 2002/ Accepted 19 August 2002

Rotavirus RNA was detected in the cerebrospinal fluid (CSF) of a child with central nervous system disease symptoms associated with rotavirus gastroenteritis. The rotavirus isolates from the fecal and CSF samples were genotyped as G1P[8]. Sequence analysis of the VP7 and VP4 proteins derived from the fecal and CSF samples were remarkably similar to each other and to G1P[8] rotavirus strains commonly circulating in the community and associated with gastroenteritis.

Present address: Enteric Virus Unit, Enteric Respiratory and Neurological Virus Laboratory, Central Public Health Laboratory, London, United Kingdom.

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