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Journal of Clinical Microbiology, February 2002, p. 637-640, Vol. 40, No. 2
0095-1137/01/$04.00+0     DOI: 10.1128/JCM.40.2.637-640.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Evaluation of Chlamydia pneumoniae and Mycoplasma pneumoniae as Etiologic Agents of Persistent Cough in Adolescents and Adults

Robert M. Wadowsky,1,2,3* Elias A. Castilla,1,3 Stella Laus,3 Anita Kozy,3 Robert W. Atchison,2,3 Lawrence A. Kingsley,2 Joel I. Ward,4 David P. Greenberg,3,5 and Adult Pertussis Vaccine Efficacy Study Group,{dagger}

Departments of Pathology,1 Pediatrics, School of Medicine,5 Department of Infectious Diseases and Microbiology, Graduate School of Public Health,,2 University of PittsburghChildren's Hospital of Pittsburgh, Pittsburgh, Pennsylvania,3 UCLA Center for Vaccine Research, Torrance, California4

Received 5 June 2001/ Returned for modification 25 September 2001/ Accepted 12 November 2001

Chlamydia pneumoniae and Mycoplasma pneumoniae were evaluated as agents of persistent cough in adolescents and adults (n = 491). Tests of 473 respiratory specimens by culture or PCR or both identified four episodes (0.8%) of M. pneumoniae-associated illness and no episodes of C. pneumoniae illness, suggesting that these bacteria do not frequently cause persistent cough.

* Corresponding author. Mailing address: Department of Pathology, Children's Hospital of Pittsburgh, 3705 Fifth Ave., Pittsburgh, PA 15213-2583. Phone: (412) 692-5314. Fax: (412) 692-6550. E-mail: wadowsr{at}chplink.chp.edu.

{dagger} Members of the Adult Pertussis Vaccine Efficacy Study Group include Stephen J. Barenkamp (Saint Louis University), David I. Bernstein (Cincinnati Children's Hospital), Robert Edelman (University of Maryland), Wendy A. Keitel (Baylor College of Medicine), and John J. Treanor (University of Rochester)

Journal of Clinical Microbiology, February 2002, p. 637-640, Vol. 40, No. 2
0095-1137/01/$04.00+0     DOI: 10.1128/JCM.40.2.637-640.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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Antimicrob. Agents Chemother. Clin. Microbiol. Rev.
Clin. Vaccine Immunol. ALL ASM JOURNALS

Copyright © 2002 by the American Society for Microbiology. All rights reserved.