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Immune Responses to the Mycobacterium tuberculosis-Specific Antigen ESAT-6 Signal Subclinical Infection among Contacts of Tuberculosis Patients

Department of Tuberculosis Immunology, Statens Serum Institute,¹ Hvidovre Hospital, Copenhagen, Denmark,⁶ Armauer Hansen Research Institute,² Black Lion Hospital,³ Hossana Regional Hospital, Ministry of Health, Hossanna, Ethiopia,⁵ Karolinska Institute, Stockholm, Sweden⁴

Received 25 April 2001/ Returned for modification 29 July 2001/ Accepted 4 November 2001

Diagnosis of latent Mycobacterium tuberculosis infection is considered essential for tuberculosis control but is hampered by the lack of specific reagents. We report that strong recognition of tuberculosis complex-specific antigen ESAT-6 by healthy household contacts of tuberculosis patients correlates with the subsequent development of active tuberculosis during a 2-year follow-up period.

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