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Journal of Clinical Microbiology, February 2002, p. 718-720, Vol. 40, No. 2
0095-1137/01/$04.00+0     DOI: 10.1128/JCM.40.2.718-720.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Culture-Negative Endocarditis Due to Chlamydia pneumoniae

R. Gdoura,1 S. Pereyre,2 I. Frikha,3 N. Hammami,1 M. Clerc,2 Y. Sahnoun,3 C. Bebear,2 M. Daoud,3 B. de Barbeyrac,2* and A. Hammami1

Laboratoire de Microbiologie,1 Departement de Cardiologie et Chirurgie Cardio-Vasculaire, Centre Hospitalier Universitaire, Sfax, Tunisia,3 Laboratoire de Bactériologie, Centre National de Référence des Infections à Chlamydia, Université de Bordeaux 2, Bordeaux, France2

Received 30 July 2001/ Returned for modification 30 September 2001/ Accepted 9 November 2001

We report on the case of a 54-year-old woman diagnosed as having culture-negative endocarditis (clinical and histopathologic evidence compatible with a recent episode of endocarditis). The responsibility of Chlamydia pneumoniae in this episode of endocarditis was suggested by a serological study and was then confirmed by the positive results of PCR and in situ hybridization tests with aortic and mitral valves tissues. To our knowledge, this is the first case of endocarditis due to C. pneumoniae confirmed by molecular biology-based techniques.

* Corresponding author. Mailing address: Laboratoire de Bactériologie, Université de Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux, Cedex, France. Phone: 33 5 57 57 16 25. Fax: 33 5 56 93 29 40. E-mail: bertille.de.barbeyrac{at}u-bordeaux2.fr.

Journal of Clinical Microbiology, February 2002, p. 718-720, Vol. 40, No. 2
0095-1137/01/$04.00+0     DOI: 10.1128/JCM.40.2.718-720.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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