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Journal of Clinical Microbiology, March 2002, p. 1048-1052, Vol. 40, No. 3
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.3.1048-1052.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Nine-Year Surveillance of Methicillin-Resistant Staphylococcus aureus in a Hospital Suggests Instability of mecA DNA Region in an Epidemic Strain

Pierre-Yves Donnio,1,2* Laurence Louvet,1 Laure Preney,1 Denis Nicolas,1 Jean-Loup Avril,1,2 and Laurent Desbordes1,2

Laboratoire de Bactériologie-Virologie, Centre Hospitalier Universitaire,1 UPRES 12-54 Microbiologie, Université de Rennes 1, 35033 Rennes Cedex 9, France2

Received 20 August 2001/ Returned for modification 17 October 2001/ Accepted 13 December 2001

The distributions of the antibiotic resistance patterns in a population of Staphylococcus aureus isolates from a teaching hospital were studied over a 9-year period. The results indicate the existence of successive major epidemic methicillin-resistant strains and the emergence of a methicillin-susceptible strain with an unusual resistance pattern. Our findings suggest that this methicillin-susceptible S. aureus strain could be derived from the dominant gentamicin-susceptible methicillin-resistant S. aureus strain with the loss of a 40-kb DNA fragment.

* Corresponding author. Mailing address: Laboratoire de Bactériologie-Virologie, Centre Hospitalier Universitaire, 2 rue Henri Le Guilloux, 35033 Rennes Cedex 9, France. Phone: 33-299-28-42-76. Fax: 33-299-28-41-59. E-mail: pierre-yves.donnio{at}chu-rennes.fr.

Journal of Clinical Microbiology, March 2002, p. 1048-1052, Vol. 40, No. 3
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.3.1048-1052.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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