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Journal of Clinical Microbiology, March 2002, p. 1100-1102, Vol. 40, No. 3
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.3.1100-1102.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Successful Outcome of Treatment of a Disseminated Infection Due to Fusarium dimerum in a Leukemia Patient

Valérie Letscher-Bru,1 France Campos,2 Jocelyn Waller,1 Raoul Randriamahazaka,2 Ermanno Candolfi,1 and Raoul Herbrecht2*

Institut de Parasitologie et de Pathologie Tropicale, Faculté de Médecine, 67000 Strasbourg,1 Département d'Hématologie et d'Oncologie, Hôpital de Hautepierre, 67098 Strasbourg, France2

Received 13 September 2001/ Returned for modification 6 November 2001/ Accepted 24 December 2001

We report the first case of proven disseminated infection due to Fusarium dimerum associated with a favorable outcome in a patient with acute leukemia and prolonged neutropenia. The patient presented persistent fever, multiple necrotic skin lesions, and bilateral pneumopathy. F. dimerum was first isolated from three blood cultures and then from a skin biopsy and a mouth wash. Microscopy of positive blood cultures showed hyphae with phialides and few curved unicellular and some rare bicellular phialoconidia, permitting immediate presumptive identification of the genus Fusarium. The patient failed to respond to conventional amphotericin B but recovered after treatment was switched to amphotericin B-lipid complex and neutrophil recovery.

* Corresponding author. Mailing address: Département d'Hématologie et d'Oncologie, Hôpital de Hautepierre, Ave. Molière, 67098 Strasbourg, France. Phone: 33 3 88 12 76 88. Fax: 33 3 88 12 76 81. E-mail: raoul.herbrecht{at}chru-strasbourg.fr.

Journal of Clinical Microbiology, March 2002, p. 1100-1102, Vol. 40, No. 3
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.3.1100-1102.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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