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Journal of Clinical Microbiology, March 2002, p. 1109-1112, Vol. 40, No. 3
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.3.1109-1112.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Staphylococcus Heterogeneously Resistant to Vancomycin in China and Antimicrobial Activities of Imipenem and Vancomycin in Combination against It

Department of Respiratory Medicine, the Third Affiliated Hospital of Sun Yatsen University of Medical Sciences, 510630 Guangzhou, People's Republic of China

Received 7 September 2001/ Returned for modification 3 November 2001/ Accepted 25 November 2001

Of 115 methicillin-resistant Staphylococcus strains collected from sputum specimens, 34 strains reduced susceptibility to vancomycin, 9 of which emerged as heterogeneous vancomycin-resistant strains (hetero-VRS), with various degrees of vancomycin resistance at a frequency of 10^-6 or higher. Seventy-six percent (19 of 25) of non-hetero-VRS and 100% (9 of 9) of hetero-VRS were susceptible to synergistic treatment with vancomycin and imipenem. Clinical clearance between 9 hetero-VRS and 25 non-hetero-VRS had an obvious statistical significance (P = 0.001). The hetero-VRS may play an important role in vancomycin therapy failure.

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