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Journal of Clinical Microbiology, March 2002, p. 1113-1115, Vol. 40, No. 3
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.3.1113-1115.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Pulmonary Colonization by Chrysosporium zonatum Associated with Allergic Inflammation in an Immunocompetent Subject

Division of Pulmonary Diseases, Department of Internal Medicine,¹ Microbiology Branch, Department of Clinical Laboratory, Saga Medical School, Saga,² Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Chiba, Japan,³ Microfungus Collection and Herbarium, Devonian Botanic Garden, University of Alberta, Edmonton, Alberta, Canada⁴

Received 5 July 2001/ Returned for modification 23 August 2001/ Accepted 2 January 2002

We report a case of noninvasive pulmonary disease due to Chrysosporium zonatum in an immunocompetent male. The fungus colonized an existing tuberculous cavity and was isolated from transbronchial lavage fluid and from a percutaneous aspiration specimen. The disease was accompanied by the unusual feature of an allergic reaction. The fungus ball was successfully treated by intracavitary administration of amphotericin B. C. zonatum is the anamorph of the heterothallic ascomycete Uncinocarpus orissi, and the identity of the case isolate was verified by formation of ascospores in mating tests with reference isolates.