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Journal of Clinical Microbiology, March 2002, p. 852-856, Vol. 40, No. 3
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.3.852-856.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Trends in Antifungal Susceptibility of Candida spp. Isolated from Pediatric and Adult Patients with Bloodstream Infections: SENTRY Antimicrobial Surveillance Program, 1997 to 2000

M. A. Pfaller,1,2* D. J. Diekema,1,3 R. N. Jones,4 S. A. Messer,1 R. J. Hollis,1 and the SENTRY Participants Group

Departments of Pathology,1 Medicine,3 Epidemiology, University of Iowa College of Medicine and College of Public Health, Iowa City, Iowa,2 The JONES Group/JMI Laboratories, North Liberty, Iowa4

Received 24 September 2001/ Returned for modification 2 December 2001/ Accepted 12 December 2001

From 1 January 1997 through 31 December 2000, 2,047 bloodstream infections (BSIs) due to Candida spp. were reported from hospitals in the United States, Canada, Latin America, and Europe participating in the SENTRY Antifungal Surveillance Program. Among individuals in four age groups (<=1, 2 to 15, 16 to 64, and >=65 years) Candida albicans was the most common species, causing 60, 55, 55, and 50% of infections, respectively. C. glabrata caused 17 to 23% of BSIs in those ages 16 to 64 and >=65 years, whereas it caused only 3% of BSIs in the individuals in the two younger age groups (P < 0.001). C. parapsilosis (which caused 21 to 24% of BSIs) and C. tropicalis (which caused 7 to 10% of BSIs) were more common than C. glabrata in individuals ages <=1 year and 2 to 15 years. Isolates of Candida spp. showed a trend of decreasing susceptibility to fluconazole, itraconazole, and amphotericin B with increasing patient age (P <= 0.01). None of the C. glabrata isolates from individuals <=1 year old were resistant to fluconazole, whereas they made up 5 to 9% of isolates from individuals ages 16 to 64 and >=65 years. Isolates of C. tropicalis from patients <=1 year old were more susceptible to flucytosine (MIC at which 90% of isolates are inhibited [MIC90], 0.5 µg/ml; 0% resistant isolates) than those from patients >=65 years old (MIC90, 32 µg/ml; 11% resistant isolates). The investigational triazoles posaconazole, ravuconazole, and voriconazole were all highly active against all species of Candida from individuals in all age groups. These data demonstrate differences in the species distributions of pathogens and differences in antifungal resistance among isolates from individuals in the pediatric and adult age groups. Ongoing surveillance will enhance efforts to limit the extent of antifungal resistance in individuals in various age groups.

* Corresponding author. Mailing address: Medical Microbiology Division, C606 GH, Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242. Phone: (319) 384-9566. Fax: (319) 356-4916. E-mail: michael-pfaller{at}uiowa.edu.

Journal of Clinical Microbiology, March 2002, p. 852-856, Vol. 40, No. 3
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.3.852-856.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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