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Journal of Clinical Microbiology, March 2002, p. 898-901, Vol. 40, No. 3
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.3.898-901.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Initial Concentration of Staphylococcus epidermidis in Simulated Pediatric Blood Cultures Correlates with Time to Positive Results with the Automated, Continuously Monitored BACTEC Blood Culture System

Yishai Haimi-Cohen,1,{dagger} Ernestine M. Vellozzi,2 and Lorry G. Rubin1*

Division of Infectious Diseases,1 Department of Pediatrics, Schneider Children's Hospital, and Department of Laboratory Medicine, Long Island Jewish Medical Center of the North Shore-Long Island Jewish Health System, New Hyde Park, New York2

Received 30 May 2001/ Returned for modification 19 September 2001/ Accepted 7 December 2001

The relationship of initial concentration of Staphylococcus epidermidis in blood cultures and time to positivity (TTP) in an automated, continuously monitored blood culture system was assessed. Blood and 1 to 1,000 CFU of S. epidermidis per ml in stationary or exponential phase were inoculated in BACTEC Pediatric Plus F bottles and incubated. The TTP was inversely proportional to the initial inoculated concentration. Blood culture bottles with initial bacterial densities of <10 CFU/ml had a TTP of >20 h (upper limit of 95% prediction interval, 20.7 h) and bottles with initial bacterial densities of >=50 CFU/ml had a TTP of <=15 h (lower limit of 95% prediction interval, 13.4 h).

* Corresponding author. Mailing address: Schneider Children's Hospital, 269-01 76th Ave., New Hyde Park, NY 11040. Phone: (718) 470-3480. Fax: (718) 470-0887. E-mail: lrubin{at}lij.edu.

{dagger} Present address: Day Care Unit, Schneider Children's Medical Center of Israel, Petah Tiqva 49100, Israel.

Journal of Clinical Microbiology, March 2002, p. 898-901, Vol. 40, No. 3
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.3.898-901.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.





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