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Journal of Clinical Microbiology, April 2002, p. 1381-1386, Vol. 40, No. 4
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.4.1381-1386.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Catheter-Related Candidemia Caused by Candida lipolytica in a Patient Receiving Allogeneic Bone Marrow Transplantation

Domenico D'Antonio,1 Ferdinando Romano,2* Eugenio Pontieri,3 Giuseppe Fioritoni,1 Claudia Caracciolo,4 Stefano Bianchini,3 Paola Olioso,1 Tommaso Staniscia,2 Roberta Sferra,4 Stefania Boccia,2 Antonella Vetuschi,4 Giovanni Federico,5 Eugenio Gaudio,4 and Giuseppe Carruba3

Servizio di Microbiologia Clinica del Dipartimento di Ematologia ed Oncologia, Ospedale "Spirito Santo," e Cattedra di Ematologia,1 Direzione Sanitaria, ASL Pescara, Pescara,5 Dipartimento di Medicina e Scienze dell'Invecchiamento, Sezione di Epidemiologia e Sanità Pubblica, Università "G. d'Annunzio," Chieti,2 Cattedra di Virologia e Micologia Medica,3 Cattedra di Anatomia Umana e Clinica, Dipartimento di Medicina Sperimentale, Università degli Studi dell'Aquila, L'Aquila, Italy4

Received 14 May 2001/ Returned for modification 28 November 2001/ Accepted 1 February 2002

Candida lipolytica was recovered from the blood and the central venous catheter in a patient receiving allogeneic bone marrow transplantation. Two C. lipolytica strains from different geographical areas and the ATCC 9773 strain of C. lipolytica were used as controls. C. lipolytica was identified by standard methods. MICs indicated antifungal susceptibilities to amphotericin B, fluconazole, and itraconazole for all strains. In vitro testing and scanning electron microscopy showed that C. lipolytica was capable of producing large amounts of viscid slime material in glucose-containing solution, likely responsible for the ability of the yeast to adhere to catheter surfaces. Restriction fragment length polymorphisms revealed an identical profile for all clinical isolates, unrelated to those observed for the control strains. This finding suggested the absence of microevolutionary changes in the population of the infecting strain, despite the length of the sepsis and the potential selective pressure of amphotericin B, which had been administered to the patient for about 20 days. The genomic differences that emerged between the isolates and the control strains were indicative of a certain degree of genetic diversity between C. lipolytica isolates from different geographical areas.

* Corresponding author. Mailing address: Dipartimento di Medicina e Scienze dell'Invecchiamento, Sezione di Epidemiologia e Sanità Pubblica, Università "G. d'Annunzio," Via dei Vestini, 5, 66013 Chieti, Italy. Phone: 0871-3554003. Fax: 0871-3554001. E-mail: Romano{at}igiene.unich.it.

Journal of Clinical Microbiology, April 2002, p. 1381-1386, Vol. 40, No. 4
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.4.1381-1386.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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