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Journal of Clinical Microbiology, February 2002, p. 1496-1499, Vol. 40, No. 4
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.4.1496-1499.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Aspergillus Galactomannan Antigen in the Cerebrospinal Fluid of Bone Marrow Transplant Recipients with Probable Cerebral Aspergillosis

Claudio Viscoli,1,2* Marco Machetti,1 Paola Gazzola,1,3 Andrea De Maria,4 Dimitri Paola,5 Maria Teresa Van Lint,6 Francesca Gualandi,6 Mauro Truini,7 and Andrea Bacigalupo6

Istituto Nazionale per la Ricerca sul Cancro,1 Dipartimento di Oncologia, Biologia e Genetica,2 Dipartimento di Scienze Neurologiche e della Visione,3 Dipartimento di Medicina Interna,4 Dipartimento di Medicina Sperimentale ,5 Dipartimento Diagnostico di Laboratorio, di Anatomia Patologica e Medico Legale, Università di Genova,7 Ospedale San Martino, Genoa, Italy6

Received 10 May 2001/ Returned for modification 26 September 2001/ Accepted 23 November 2001

The Aspergillus galactomannan test was performed on cerebrospinal fluid and serum samples from 5 patients with probable cerebral aspergillosis and from 16 control patients. Cerebrospinal fluid galactomannan levels were significantly higher in aspergillosis patients, and most galactomannan was produced intrathecally. Comparison of serum galactomannan values in pulmonary and cerebral aspergillosis patients showed significant overlapping. Detection of Aspergillus galactomannan in cerebrospinal fluid may be diagnostic of cerebral aspergillosis.

* Corresponding author. Mailing address: Istituto Nazionale per la Ricerca sul Cancro, Largo Rosanna Benzi 10, 16132 Genoa, Italy. Phone: 39-010-5600846 or -5600848. Fax: 39-010-5600264. E-mail: viscolic{at}unige.it.

Journal of Clinical Microbiology, February 2002, p. 1496-1499, Vol. 40, No. 4
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.4.1496-1499.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.





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