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Journal of Clinical Microbiology, April 2002, p. 1522-1525, Vol. 40, No. 4
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.4.1522-1525.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Introduction of New Clones of Penicillin-Nonsusceptible Streptococcus pneumoniae in Hong Kong

Margaret Ip,1* Donald J. Lyon,1 Raymond W. H. Yung,2 Lily Tsang,1 and Augustine F. B. Cheng1

Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin ,1 Pamela Youde Nethersole Eastern Hospital, Hong Kong2

Received 17 August 2001/ Returned for modification 17 October 2001/ Accepted 10 January 2002

Analysis of penicillin-nonsusceptible Streptococcus pneumoniae (PNSP) isolates in Hong Kong by use of a combination of antibiogram typing, serotyping, multilocus sequence typing, and pulsed-field gel electrophoresis indicated that the dissemination of PNSP was the result of the spread of international clones: variants of the Spain23F-1 or Spain6B-2 clones were the predominant PNSP isolates from 1994 to 1997 and remained so, but Taiwan19F-14 and Taiwan serotype 6B clones were disseminated in Hong Kong in 1999 and 2000. Concomitant changes in antibiotic susceptibility profiles, with the rate of susceptibility to chloramphenicol rising from 10% in the period from 1994 to 1997 to 31% (P < 0.001) in 1999 and 2000, were noted to accompany the shift of clones.

* Corresponding author. Mailing address: Department of Microbiology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong. Phone: (852) 2632 2306. Fax: (852) 2647 3227. E-mail: margaretip{at}cuhk.edu.hk.

Journal of Clinical Microbiology, April 2002, p. 1522-1525, Vol. 40, No. 4
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.4.1522-1525.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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