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Journal of Clinical Microbiology, April 2002, p. 1522-1525, Vol. 40, No. 4
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.4.1522-1525.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Introduction of New Clones of Penicillin-Nonsusceptible Streptococcus pneumoniae in Hong Kong

Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin ,¹ Pamela Youde Nethersole Eastern Hospital, Hong Kong²

Received 17 August 2001/ Returned for modification 17 October 2001/ Accepted 10 January 2002

Analysis of penicillin-nonsusceptible Streptococcus pneumoniae (PNSP) isolates in Hong Kong by use of a combination of antibiogram typing, serotyping, multilocus sequence typing, and pulsed-field gel electrophoresis indicated that the dissemination of PNSP was the result of the spread of international clones: variants of the Spain^23F-1 or Spain^6B-2 clones were the predominant PNSP isolates from 1994 to 1997 and remained so, but Taiwan^19F-14 and Taiwan serotype 6B clones were disseminated in Hong Kong in 1999 and 2000. Concomitant changes in antibiotic susceptibility profiles, with the rate of susceptibility to chloramphenicol rising from 10% in the period from 1994 to 1997 to 31% (P < 0.001) in 1999 and 2000, were noted to accompany the shift of clones.

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