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Journal of Clinical Microbiology, May 2002, p. 1648-1650, Vol. 40, No. 5
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.5.1648-1650.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Disseminated Toxoplasmosis, Resulting from Infection of Allograft, after Orthotopic Liver Transplantation: Usefulness of Quantitative PCR

F. Botterel,1* P. Ichai,2 C. Feray,2 P. Bouree,1 F. Saliba,2 R. Tur Raspa,3 D. Samuel,2 and S. Romand1,4

Service de Microbiologie, Departement de Parasitologie-Mycologie, Hopital de Bicetre, Faculté de Médecine Paris-Sud, 94275 Kremlin-Bicetre Cedex,1 Centre Hépatobiliaire, Paul Brousse Hospital, 94804 Villejuif,2 Institut de Puericulture, F 75014 Paris, France,4 Liver Unit, Rabin Medical Center, Tel Aviv, Israel3

Received 4 September 2001/ Returned for modification 4 December 2001/ Accepted 12 February 2002

Disseminated toxoplasmosis is a life-threatening disease in liver transplant recipients that can result from an organ-transmitted infection. We report here a case of fatal disseminated toxoplasmosis after orthotopic liver transplantation from a seropositive donor (immunoglobulin G [IgG]+ and IgM-) in a patient who was nonimmune for toxoplasmosis prior to transplantation. Quantitative PCR analyses of various clinical specimens, including serum samples, appeared retrospectively to be a valuable diagnostic tool that might guide therapeutic attitudes.

* Corresponding author. Mailing address: Parasitology and Mycology Department, Le Kremlin-Bicetre Hospital, 78, rue du Général Leclerc, Paris XI University, F 94275 Le Kremlin-Bicetre, France. Phone: (33) 1-45-21-33-21. Fax: (33) 1-45-21-33-19. E-mail: francoise.botterel{at}bct.ap-hop-paris.fr.

Journal of Clinical Microbiology, May 2002, p. 1648-1650, Vol. 40, No. 5
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.5.1648-1650.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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