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Journal of Clinical Microbiology, May 2002, p. 1811-1813, Vol. 40, No. 5
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.5.1811-1813.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Correlation between the Elastase Activity Index and Invasiveness of Clinical Isolates of Aspergillus fumigatus

Jose L. Blanco,1 Raquel Hontecillas,1 Emilio Bouza,2* Isabel Blanco,1 Teresa Pelaez,2 Patricia Muñoz,2 Jose Perez Molina,2 and Marta E. Garcia1

Departamento Patología Animal I, Facultad de Veterinaria, Universidad Complutense de Madrid, 28040 Madrid,1 Servicio do Microbiologia Clinica y Enfermedades Infecciosas, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain2

Received 23 October 2000/ Returned for modification 14 December 2000/ Accepted 10 January 2002

We calculated an elastase activity index (EAI) by dividing the diameter of the elastin lysis halo by the fungal growth diameter. After 10 days' incubation at 37°C, all strains but one obtained from invasive aspergillosis showed an EAI >= 1. Of the 18 strains obtained from colonized patients, only 4 (22.2%) had an EAI >= 1, whereas neither of the strains isolated from patients with fungus ball reached this value. Overall, 44 out of the 142 strains obtained from the environment had an EAI >= 1 (30.9%).

* Corresponding author. Mailing address: Servicio de Microbiología Clínica y Enfermedades Infecciosas, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain. Phone: 34 91 586 8453. Fax: 34 91 504 4906. E-mail: ebouza{at}microb.net.

Journal of Clinical Microbiology, May 2002, p. 1811-1813, Vol. 40, No. 5
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.5.1811-1813.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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