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Recovery of an Unusual Fusogenic Herpes Simplex Virus Type 2 Strain from a Clinical Specimen

Department of Microbiology, Brigham Young University, Provo, Utah 84602, and MicroVir Laboratories, Inc., Orem, Utah 84097

Received 1 October 2001/ Returned for modification 24 December 2001/ Accepted 4 February 2002

A highly unusual herpes simplex virus type 2 strain, strain Burr, was isolated from a female genital tract clinical specimen. This virus induced remarkably rapid and extensive syncytium formation in Vero cells involving hundreds of cells but was less fusion active in HEp-2 cells, MRC-5 cells, and mink lung cells. Virus-infected cells produced the glycoproteins gB, gC, gD and gE.