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Journal of Clinical Microbiology, May 2002, p. 1831-1833, Vol. 40, No. 5
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.5.1831-1833.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

In Vitro Activities of Terbinafine in Combination with Fluconazole, Itraconazole, Voriconazole, and Posaconazole against Clinical Isolates of Candida glabrata with Decreased Susceptibility to Azoles

Sofia Perea,1* Gloria Gonzalez,2 Annette W. Fothergill,2 Deanna A. Sutton,2 and Michael G. Rinaldi2,3

Department of Medicine, Division of Infectious Diseases,1 Department of Pathology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284-7881,2 Audie Murphy Division, South Texas Veterans Health Care System, San Antonio, Texas 78284-77503

Received 15 November 2001/ Returned for modification 12 December 2001/ Accepted 26 February 2002

A checkerboard microdilution method, performed according to the recommendations of the National Committee for Clinical Laboratory Standards, was used to study the in vitro interaction of terbinafine (TRB) with fluconazole (FLU), itraconazole (ITRA), voriconazole (VRC), and posaconazole (PSZ) in 24 isolates of Candida glabrata with decreased susceptibility to azoles isolated from the oral cavities of human immunodeficiency virus patients. Synergy, defined as a fractional inhibitory concentration index of <=0.5, was observed in 17% of TRB-FLU interactions, 21% of TRB-ITRA interactions, 33% of TRB-VRC interactions, and 12% of TRB-PSZ interactions. Where synergy was not achieved, there was still a decrease in the MIC of one or both drugs when used in combination. Antagonism was not observed in any drug combination. Clinical studies are warranted to elucidate the potential utility of these combination therapies.

* Corresponding author. Mailing address: Department of Medicine, Division of Infectious Diseases, University of Texas Health Science Center, San Antonio, 7703 Floyd Curl Dr., Mail Code 7881, San Antonio, TX 78229-3900. Phone: (210) 567-1981. Fax: (210) 567-3303. E-mail: perea{at}uthscsa.edu.

Journal of Clinical Microbiology, May 2002, p. 1831-1833, Vol. 40, No. 5
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.5.1831-1833.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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