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Diversity of Rotavirus Strains among Children with Acute Diarrhea in China: 1998-2000 Surveillance Study

Institute of Virology, Chinese Academy of Preventive Medicine, Beijing,¹ and Beijing Friendship Hospital,,² Changchun Children's Hospital, Changchun,⁴ Lulong Anti-epidemic Station, Qinhuangdao,³ Kunming Children's Hospital, Kunming,⁵ Fujian Anti-epidemic Station, Fuzhou,⁶ Guangzhou Children's Hospital, Guangzhou,⁷ Zhejiang Anti-epidemic Station, Hangzhou,⁸ Zhengzhou Children's Hospital, Zhengzhou,⁹ Lanzhou Medical College, Lanzhou,¹⁰ Sichuan Anti-epidemic Station, Chengdu, China,¹¹ Viral Gastroenteritis Section, Centers for Disease Control and Prevention, Atlanta, Georgia,¹² Department of Vaccines and Biologicals, World Health Organization, Geneva, Switzerland,¹³

Received 5 October 2001/ Returned for modification 26 November 2001/ Accepted 14 February 2002

As part of a national rotavirus surveillance activity, we collected fecal specimens from 3,177 children with acute diarrhea in 10 regions of China between April 1998 and April 2000 and screened them for rotavirus. Rotavirus was detected in 41% (n = 1,305) of specimens, and in these, G1 was the predominant serotype (72.6%), followed by G3 (14.2%), G2 (12.1%), G4 (2.5%), G9 (0.9%), and G untypeable (0.7%). Among 327 G-typed strains tested for P genotype, 14 different P-G combinations were identified, with the globally common strains P[8]G1, P[4]G2, P[8]G3, and P[8]G4 representing 75.6% of all typed rotavirus strains. Among the uncommon strains, 11 were P[6]G9, and others included P[6]G1, P[6]G3, and five novel P-G combinations (P[9]G1, P[4]G1, P[4]G3, P[4]G4, and P[8]G2). Our results indicate that while the common rotavirus strains remain predominant, the diversity of strains is much greater than was previously recognized.

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