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Journal of Clinical Microbiology, June 2002, p. 2234-2237, Vol. 40, No. 6
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.6.2234-2237.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Direct Detection of Helicobacter pylori Mutations Associated with Macrolide Resistance in Gastric Biopsy Material Taken from Human Immunodeficiency Virus-Infected Subjects

Paolo Scarpellini,1* Paola Carrera,2 Annalisa Cavallero,3 Massimo Cernuschi,1 Gianni Mezzi,4 Pier Alberto Testoni,4 Anna Zingale,1 and Adriano Lazzarin1

Infectious Diseases Division,1 Clinical Molecular Biology,2 Microbiology Laboratory,3 Gastroenterology Unit, San Raffaele Scientific Institute, Milan, Italy4

Received 26 September 2001/ Returned for modification 31 January 2002/ Accepted 5 April 2002

One hundred forty gastric biopsies were tested by microbiological methods and by amplifying a sequence of 23S rRNA and identifying mutations associated to clarithromycin resistance. Seventy-six specimens were positive for Helicobacter pylori. Mutational analysis revealed alterations in 18 (39.1%) of 46 and 2 (8.7%) of 23 samples from human immunodeficiency virus-seropositive and -seronegative persons, respectively. The results of the mutational analysis fully correlated with those of the susceptibility tests.

* Corresponding author. Mailing address: Infectious Diseases Division, San Raffaele Scientific Institute, Via Stamira D'Ancona 20, 20127 Milan, Italy. Phone: 39-02-2643-7930. Fax: 39-02-2643-7989. E-mail: scarpellini.paolo{at}hsr.it.

Journal of Clinical Microbiology, June 2002, p. 2234-2237, Vol. 40, No. 6
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.6.2234-2237.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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Antimicrob. Agents Chemother. Clin. Microbiol. Rev.
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Copyright © 2002 by the American Society for Microbiology. All rights reserved.