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Discrimination between Cases of Duodenal Ulcer and Gastritis on the Basis of Putative Virulence Factors of Helicobacter pylori

Yoshio Yamaoka,^1* Julianne Souchek,² Stefan Odenbreit,³ Rainer Haas,³ Anna Arnqvist,^4,5 Thomas Borén,⁵ Tadashi Kodama,⁶ Michael S. Osato,¹ Oscar Gutierrez,⁷ Jong G. Kim,^8, and David Y. Graham¹

Department of Medicine,¹ Department of Health Services Research, Baylor College of MedicineVeterans Affairs Medical Center, Houston, Texas;,² Max Von Pettenkofer-Institut, München, Germany,³ Division of Oral Microbiology, Department of Odontology,⁴ Department of Molecular Biology, Umeå University, Umeå, Sweden,⁵ Third Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan,⁶ Universidad Nacional de Colombia, Bogota, Colombia,⁷ Guro Hospital, Korea University College of Medicine, Seoul, Korea⁸

Received 22 January 2002/ Returned for modification 24 March 2002/ Accepted 2 April 2002

The BabA, cagA, and vacA statuses of 827 Helicobacter pylori isolates were used in logistic regression models to discriminate duodenal ulcer from gastritis. Only BabA was a candidate for a universal virulence factor, but the low c statistic value (0.581) indicates that none of these factors were helpful in predicting the clinical presentation.

Deceased.

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