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Journal of Clinical Microbiology, June 2002, p. 2244-2246, Vol. 40, No. 6
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.6.2244-2246.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Discrimination between Cases of Duodenal Ulcer and Gastritis on the Basis of Putative Virulence Factors of Helicobacter pylori

Yoshio Yamaoka,1* Julianne Souchek,2 Stefan Odenbreit,3 Rainer Haas,3 Anna Arnqvist,4,5 Thomas Borén,5 Tadashi Kodama,6 Michael S. Osato,1 Oscar Gutierrez,7 Jong G. Kim,8,{dagger} and David Y. Graham1

Department of Medicine,1 Department of Health Services Research, Baylor College of MedicineVeterans Affairs Medical Center, Houston, Texas;,2 Max Von Pettenkofer-Institut, München, Germany,3 Division of Oral Microbiology, Department of Odontology,4 Department of Molecular Biology, Umeå University, Umeå, Sweden,5 Third Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan,6 Universidad Nacional de Colombia, Bogota, Colombia,7 Guro Hospital, Korea University College of Medicine, Seoul, Korea8

Received 22 January 2002/ Returned for modification 24 March 2002/ Accepted 2 April 2002

The BabA, cagA, and vacA statuses of 827 Helicobacter pylori isolates were used in logistic regression models to discriminate duodenal ulcer from gastritis. Only BabA was a candidate for a universal virulence factor, but the low c statistic value (0.581) indicates that none of these factors were helpful in predicting the clinical presentation.

* Corresponding author. Mailing address: Veterans Affairs Medical Center (111D), 2002 Holcombe Blvd., Houston, TX 77030. Phone: (713) 794-7234. Fax: (713) 790-1040. E-mail: yyamaoka{at}bcm.tmc.edu.

{dagger} Deceased.

Journal of Clinical Microbiology, June 2002, p. 2244-2246, Vol. 40, No. 6
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.6.2244-2246.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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