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Journal of Clinical Microbiology, June 2002, p. 2266-2269, Vol. 40, No. 6
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.6.2266-2269.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Transient Fungemia Caused by an Amphotericin B-Resistant Isolate of Candida haemulonii

Departamento Micología, INEI, ANLIS Dr. Carlos G. Malbrán,¹ Servicio de Infectología,³ Servicio de Microbiología, Hospital Fernández, Buenos Aires, Argentina,⁴ Servicio de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, 28220 Majadahonda, Spain²

Received 13 November 2001/ Returned for modification 2 February 2002/ Accepted 7 March 2002

A bloodstream infection due to Candida haemulonii afflicting a patient with fever and a medical history of megaloblastic anemia is reported. The clinical isolate was misidentified by the API 20C and VITEK identification systems. The results of susceptibility tests showed that the MIC of amphotericin B for C. haemulonii was 4 µg/ml. Additional susceptibility testing procedures based on the use of antibiotic medium 3 and Iso-Sensitest broth were performed, and killing curves were determined. Two collection strains of C. haemulonii were employed as controls. The three isolates exhibited resistance to amphotericin B in vitro regardless of the antifungal susceptibility testing method employed. In addition, the MICs of fluconazole for the three isolates were high. Further studies are needed in order to ascertain whether this species exhibits innate or acquired resistance to amphotericin B and other antifungal agents.

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