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Journal of Clinical Microbiology, July 2002, p. 2331-2334, Vol. 40, No. 7
0095-1137/02/$04.00+0 DOI: 10.1128/JCM.40.7.2331-2334.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.
James R. Appleman,3,
Craig D. Shimasaki,3 and Komandoor E. Achyuthan3
University of MissouriKansas City School of Medicine,1 The Children's Mercy Hospital, Kansas City, Missouri,2 ZymeTx, Inc., Oklahoma City, Oklahoma3
Received 15 January 2002/ Returned for modification 1 March 2002/ Accepted 5 April 2002
Exploiting the high sensitivity of the chemiluminescence phenomenon, an accurate and sensitive point-of-care test, called the ZstatFlu-II test (ZymeTx, Inc., Oklahoma City, Okla.), was developed to detect influenza virus infections. The ZstatFlu-II test takes 20 min and requires approximately 2 min of "hands-on" time for operational steps. The ZstatFlu-II test does not distinguish between infections with influenza virus types A and B. ZstatFlu-II test results are printed on Polaroid High-Speed Detector Film, allowing test results to be archived. A prototype version of the ZstatFlu-II test was evaluated during the 2000-to-2001 flu season with 300 nasal aspirate specimens from children at a pediatric hospital. Compared to culture, the ZstatFlu-II test had 88% sensitivity and 92% specificity. The Directigen test had a sensitivity of 75% and a specificity of 93%. The sensitivity of the ZstatFlu-II test was significantly higher than that of the Directigen test (P < 0.0574).
Present address: National Center for Toxicological Research, Jefferson, AR 72079.
Present address: Anadys Pharmaceuticals, Inc., San Diego, CA 92121.
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