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Journal of Clinical Microbiology, July 2002, p. 2612-2615, Vol. 40, No. 7
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.7.2612-2615.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Seroprevalence of Antibodies That React with Anaplasma phagocytophila, the Agent of Human Granulocytic Ehrlichiosis, in Different Populations in Westchester County, New York

Maria E. Aguero-Rosenfeld,1,2* Lorraine Donnarumma,3 Lois Zentmaier,2 Jobby Jacob,3 Michael Frey,4 Richard Noto,4 Carol A. Carbonaro,3 and Gary P. Wormser2

Division of Infectious Diseases, Department of Medicine,,2 Department of Pathology,,1 Department of Pediatrics, New York Medical College,4 Westchester Medical Center, Valhalla, New York 105953

Received 28 January 2002/ Returned for modification 24 March 2002/ Accepted 10 April 2002

We determined the frequencies of antibodies to Anaplasma phagocytophila, the agent of human granulocytic ehrlichiosis (HGE), in different groups of adults and children from Westchester County, New York. The groups included 159 adult blood donors and 215 children who were seronegative for Borrelia burgdorferi antibodies, 118 adult patients and 57 children who were seropositive for B. burgdorferi antibodies, and 42 adult patients with culture-confirmed erythema migrans. Eighteen (11.3%) of the blood donors and 11 (5.1%) of the B. burgdorferi-seronegative children were found to have A. phagocytophila antibodies by indirect immunofluorescent-antibody assay (IFA). Nine of 42 (21.4%) patients with culture-confirmed erythema migrans tested at the baseline visit, 42 of 118 (35.6%) adults, and 3 of 57 (5.3%) children whose sera were reactive for B. burgdorferi antibodies also tested positive for A. phagocytophila antibodies. The geometric mean titer ranged from 219 to 315 for all groups, and the differences in titers among the groups were not statistically significant. Only one-third of the healthy blood donors reactive by IFA were confirmed to be positive by immunoblotting. We conclude that a significant proportion of adults and children without clinical evidence of HGE will test positive for A. phagocytophila antibodies when the conventional cutoff titer of 80 is used in the IFA. This information must be considered in interpretation of test results.

* Corresponding author. Mailing address: Clinical Laboratories, Room 1J-11a, Westchester Medical Center, Valhalla, NY 10595. Phone (914) 493-7389. Fax: (914) 493-5742. E-mail: m_aguero-rosenfeld{at}nymc.edu.

Journal of Clinical Microbiology, July 2002, p. 2612-2615, Vol. 40, No. 7
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.7.2612-2615.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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