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Journal of Clinical Microbiology, July 2002, p. 2622-2625, Vol. 40, No. 7
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.7.2622-2625.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Virulence Genes in Helicobacter pylori Strains from West Bengal Residents with Overt H. pylori-Associated Disease and Healthy Volunteers

Santanu Chattopadhyay,1 Simanti Datta,1 Abhijit Chowdhury,2 Sujit Chowdhury,2 Asish K. Mukhopadhyay,3 K. Rajendran,1 S. K. Bhattacharya,1 Douglas E. Berg,3 and G. Balakrish Nair1,4*

National Institute of Cholera and Enteric Diseases,1 Department of Gastroenterology, Institute of Post Graduate Medical Education and Research, Calcutta, India,2 Department of Molecular Microbiology, Washington University Medical School, St. Louis, Missouri 63110,3 International Centre for Diarrhoeal Diseases Research, Dhaka, Bangladesh4

Received 18 January 2002/ Returned for modification 12 March 2002/ Accepted 21 April 2002

We compared putative molecular markers of virulence (vacA, cagA, and iceA) of Helicobacter pylori strains isolated from 52 adult duodenal ulcer patients from West Bengal, India, with those of H. pylori strains isolated from 48 adult healthy volunteers from the same region. On the basis of genotyping by PCR, we conclude that the H. pylori strains isolated from the two study groups were indistinguishable and that there are geographic variations in the association of certain putative H. pylori virulence genes with clinical status.


* Corresponding author. Mailing address: National Institute of Cholera and Enteric Diseases, P-33, CIT Rd., Scheme XM, Beliaghata, P.O. Box 177, Calcutta 700010, India. Phone: 91-33-350-4598. Fax: 91-33-350-5066. E-mail: gbnair{at}icddrb.org.


Journal of Clinical Microbiology, July 2002, p. 2622-2625, Vol. 40, No. 7
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.7.2622-2625.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.




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