This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hahn, R. C.
Right arrow Articles by Hamdan, J. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hahn, R. C.
Right arrow Articles by Hamdan, J. S.

 Previous Article  |  Next Article 

Journal of Clinical Microbiology, August 2002, p. 2828-2831, Vol. 40, No. 8
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.8.2828-2831.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

In Vitro Comparison of Activities of Terbinafine and Itraconazole against Paracoccidioides brasiliensis

R. C. Hahn,1 C. J. F. Fontes,2 R. D. Batista,1 and J. S. Hamdan1*

Department of Microbiology, Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais,1 Núcleo de Estudos de Doenças Infecciosas e Tropicais, TRÓPICA, Faculdade de Ciências Médicas, Universidade Federal de Mato Grosso, Cuiaba, Mato Grosso, Brazil2

Received 24 July 2001/ Returned for modification 24 December 2001/ Accepted 8 May 2002

In vitro, terbinafine is highly active against a broad spectrum of pathogenic fungi. We evaluated the activities of terbinafine and itraconazole against 31 isolates of Paracoccidioides brasiliensis. The tests were conducted by using a broth macrodilution procedure. MICs, in micrograms per milliliter, were as follows: terbinafine, 0.015 to 1.0 (geometric mean, 0.1188); itraconazole, 0.007 to 0.5 (geometric mean, 0.03165). The usual therapy for paracoccidioidomycosis is sulfonamides, amphotericin B, and azole derivatives (ketoconazole, itraconazole, and fluconazole). In comparison to amphotericin B, azole derivatives allow shorter treatment courses, can be administered orally, and are equally effective. Itraconazole has as high efficacy as ketoconazole, but with superior tolerance. It is the current drug of choice for treatment of paracoccidioidomycosis. The data obtained in this study indicate that terbinafine is active against P. brasiliensis in vitro and suggest that this allylamine can be considered a new option as drug therapy for paracoccidioidomycosis.

* Corresponding author. Mailing address: Departamento de Microbiologia, ICB/UFMG, Av. Antônio Carlos, 6627, 31270-901 Belo Horizonte, Minas Gerais, Brazil. Phone: 55 31 3499-2758. Fax: 55 31 3499-2730. E-mail: handan{at}icb.ufmg.br.

Journal of Clinical Microbiology, August 2002, p. 2828-2831, Vol. 40, No. 8
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.8.2828-2831.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Kohler, L. M., Monteiro, P. C. F., Hahn, R. C., Hamdan, J. S. (2004). In Vitro Susceptibilities of Isolates of Sporothrix schenckii to Itraconazole and Terbinafine. J. Clin. Microbiol. 42: 4319-4320 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»