This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Queiroz, D. M. M.
Right arrow Articles by Nogueira, A. M. M. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Queiroz, D. M. M.
Right arrow Articles by Nogueira, A. M. M. F.

 Previous Article  |  Next Article 

Journal of Clinical Microbiology, August 2002, p. 2849-2853, Vol. 40, No. 8
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.8.2849-2853.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Role of Corpus Gastritis and cagA-Positive Helicobacter pylori Infection in Reflux Esophagitis

Dulciene Maria Magalhães Queiroz,1* Gifone Aguiar Rocha,1 Celso Affonso de Oliveira,1 Andreia Maria Camargos Rocha,1 Adriana Santos,1 Mônica Maria Demas Álvares Cabral,2 and Ana Margarida Miguel Ferreira Nogueira2

Laboratory of Research in Bacteriology,1 Department of Pathology, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil2

Received 5 February 2002/ Returned for modification 7 April 2002/ Accepted 18 May 2002

Considering that the role of Helicobacter pylori infection in gastroesophageal reflux and reflux esophagitis (GERD) is still controversial and that the role of virulence markers of the bacterium has not been evaluated in most studies of GERD, we investigated the association among H. pylori infection with cagA-positive and -negative strains, corpus gastritis, and GERD in a large group of patients by controlling for confounding factors. We studied prospectively 281 consecutive adult patients: 93 with GERD and 188 controls. H. pylori infection status was diagnosed by culture, by the preformed urease test, with a carbolfuchsin-stained smear, and by histology. The cagA status was determined by PCR of H. pylori isolates and gastric biopsy specimens. H. pylori infection was diagnosed in 191 (68.0%) of 281 patients. Among the 93 patients with GERD, 84 presented with mild or moderate esophagitis and 9 presented with severe esophagitis. In the multivariate analysis, the age of the patients and the degree of oxyntic gastritis were associated with GERD. Among the strains isolated from patients with GERD and from the control group, 24.4 and 66.9%, respectively, were positive for cagA (P < 0.001). Compared to infection with cagA-negative strains, infection with cagA-positive H. pylori strains was associated with a more intense gastritis in the corpus (P = 0.001). cagA status (odds ratio [OR] = 0.16, 95% confidence interval [CI] = 0.07 to 0.40), gastritis of the corpus (OR = 0.69, 95% CI = 0.48 to 0.99), and age (OR = 1.04, 95% CI = 1.01 to 1.07) were associated with GERD. In conclusion, the study provides evidence supporting the independent protective roles of cagA-positive H. pylori strains and the degree of corpus gastritis against GERD.

* Corresponding author. Mailing address: Faculdade de Medicina, UFMG, Av. Alfredo Balena, 190, sala 4026, 30130-100, Belo Horizonte, Brazil. Phone and fax: (55-31) 32742767. E-mail: dqueiroz{at}medicina.ufmg.br.

Journal of Clinical Microbiology, August 2002, p. 2849-2853, Vol. 40, No. 8
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.8.2849-2853.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Farinati, F., Cardin, R., Russo, V. M., Busatto, G., Franco, M., Falda, A., Mescoli, C., Rugge, M. (2004). Differential Effects of Helicobacter pylori Eradication on Oxidative DNA Damage at the Gastroesophageal Junction and at the Gastric Antrum. Cancer Epidemiol. Biomarkers Prev. 13: 1722-1728 [Abstract] [Full Text]  
  • Blaser, M. J. (2002). Polymorphic Bacteria Persisting in Polymorphic Hosts: Assessing Helicobacter pylori-Related Risks for Gastric Cancer. JNCI J Natl Cancer Inst 94: 1662-1663 [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»