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Journal of Clinical Microbiology, August 2002, p. 2866-2875, Vol. 40, No. 8
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.8.2866-2875.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Analysis of Phylogenetic Relationship of Cylindrocarpon lichenicola and Acremonium falciforme to the Fusarium solani Species Complex and a Review of Similarities in the Spectrum of Opportunistic Infections Caused by These Fungi

R. C. Summerbell* and H.-J. Schroers

Centraalbureau voor Schimmelcultures, Utrecht, The Netherlands

Received 7 December 2001/ Returned for modification 7 March 2002/ Accepted 18 May 2002

An emerging pattern of similarity in medical case reports led to a project to compare the phylogenetic affinities of two well-known tropical fungal opportunistic pathogens, Cylindrocarpon lichenicola and Acremonium falciforme, to members of the Fusarium solani species complex. C. lichenicola and A. falciforme, despite their deviating conidial morphologies, were shown via sequencing of the ribosomal large subunit to be well instituted within a clade mainly consisting of typical F. solani strains and other species until recently considered variants of F. solani. The original name Fusarium lichenicola C. B. Massalongo is reestablished, and the new combination F. falciforme is made. Recognition of these species as fusaria is necessary for correct interpretation of current and future molecular diagnostic tests. Reevaluation of species morphology in light of the molecular findings showed that certain features, especially elongate filiform conidiophores with integrated terminal phialides, facilitate correct microscopic classification of these atypical Fusarium species. There is a strong and underrecognized overlap in the spectra of cases caused by members of the F. solani clade, particularly ocular infections, mycetomas, and, in the neutropenic host, disseminated and other serious systemic infections. A novel synthesis of case reports shows that patients from areas with warm climates may develop a distinctive fusarial intertrigo caused by F. solani, Fusarium lichenicola, or Fusarium oxysporum.

* Corresponding author: Mailing address: Centraalbureau voor Schimmelcultures, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands. Phone: 31 30 212 2688. Fax: 31 30 251 2097. E-mail: summerbell{at}cbs.knaw.nl.

Journal of Clinical Microbiology, August 2002, p. 2866-2875, Vol. 40, No. 8
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.8.2866-2875.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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