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Journal of Clinical Microbiology, August 2002, p. 3100-3103, Vol. 40, No. 8
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.8.3100-3103.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

CASE REPORT

Unique Case of Helicobacter sp. Osteomyelitis in an Immunocompetent Child Diagnosed by Broad-Range 16S PCR

Kathryn A. Harris,1* Katy J. Fidler,2 John C. Hartley,1 Julie Vogt,2 Nigel J. Klein,2 Fergal Monsell,3 and Vas M. Novelli2

Department of Microbiology,1 Department of Infectious Diseases,2 Department of Orthopaedics, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom3

Received 2 November 2001/ Returned for modification 2 January 2002/ Accepted 27 May 2002

ABSTRACT

We report the first case of Helicobacter sp. osteomyelitis in an immunocompetent child. The infection was diagnosed by broad-range 16S PCR followed by sequencing of the resulting amplicon. All other microbiological investigations proved negative. This case highlights the importance of molecular methods in the diagnosis of unsuspected etiological agents and the potential role of Helicobacter sp. in human infection.

* Corresponding author. Mailing address: Department of Microbiology, Level 4 Camelia Botnar Laboratories, Great Ormond Street Hospital for Children NHS Trust, Great Ormond Street, London, WC1N 3JH, United Kingdom. Phone: 44 207 405 9200. Fax: 44 207 813 8268. E-mail: harrik2{at}gosh.nhs.uk.

Journal of Clinical Microbiology, August 2002, p. 3100-3103, Vol. 40, No. 8
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.8.3100-3103.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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