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Journal of Clinical Microbiology, August 2002, p. 3104-3106, Vol. 40, No. 8
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.8.3104-3106.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

CASE REPORT

Sicca Syndrome Associated with Tropheryma whipplei Intestinal Infection

Cesare Bosman,1 Renata Boldrini,2 Giuliana Borsetti,3 Sergio Morelli,3 Maria Grazia Paglia,4 and Paolo Visca4,5*

Department of Experimental Medicine and Pathology,1 Department of Medical Sciences, "La Sapienza" University,3 Department of Pathology, Bambino Gesù Pediatric Hospital,2 Molecular Microbiology Unit, National Institute for Infectious Diseases, "Lazzaro Spallanzani," IRCCS,4 Department of Biology, "Roma Tre" University, Rome, Italy5

Received 22 January 2002/ Returned for modification 24 March 2002/ Accepted 6 May 2002

ABSTRACT

The case of a 61-year-old woman with Whipple's disease-associated sicca complex is reported. Tropheryma whipplei infection was diagnosed by histological and ultrastructural examination of the jejunal mucosa and sequence analysis of the bacterial 16S ribosomal DNA. The role of vitamin A malabsorption in sicca complex secondary to Whipple's disease is discussed.

* Corresponding author. Mailing address: Department of Biology, "Roma Tre" University, Viale G. Marconi, 446-00146 Rome, Italy. Phone: 39.06.55176347. Fax: 39.06.55176321. E-mail: visca{at}bio.uniroma3.it.

Journal of Clinical Microbiology, August 2002, p. 3104-3106, Vol. 40, No. 8
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.8.3104-3106.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.





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