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Journal of Clinical Microbiology, September 2002, p. 3184-3191, Vol. 40, No. 9
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.9.3184-3191.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Molecular Characterization of Multiresistant d-Tartrate-Positive Salmonella enterica Serovar Paratyphi B Isolates

Angelika Miko, Beatriz Guerra, Andreas Schroeter, Christina Dorn, and Reiner Helmuth*

National Salmonella Reference Laboratory, Federal Institute for Health Protection of Consumers and Veterinary Medicine, 12277 Berlin, Germany

Received 18 December 2001/ Returned for modification 7 April 2001/ Accepted 20 June 2002

Since 1996, the National Salmonella Reference Laboratory of Germany has received an increasing number of Salmonella enterica subsp. enterica serovar Paratyphi B isolates. Nearly all of these belonged to the dextrorotatory tartrate-positive variant (S. enterica subsp. enterica serovar Paratyphi B dT+), formerly called S. enterica subsp. enterica serovar Java. A total of 55 selected contemporary and older S. enterica subsp. enterica serovar Paratyphi B dT+ isolates were analyzed by plasmid profiling, antimicrobial resistance testing, pulsed-field gel electrophoresis, IS200 profiling, and PCR-based detection of integrons. The results showed a high genetic heterogeneity among 10 old strains obtained from 1960 to 1993. In the following years, however, new distinct multiresistant S. enterica subsp. enterica serovar Paratyphi B dT+ clones emerged, and one clonal lineage successfully displaced the older ones. Since 1994, 88% of the isolates investigated were multiple drug resistant. Today, a particular clone predominates in some German poultry production lines, poultry products, and various other sources. It was also detected in contemporary isolates from two neighboring countries as well.

* Corresponding author. Mailing address: Federal Institute for Health Protection of Consumers and Veterinary Medicine (BgVV), Diedersdorfer Weg 1, 12277 Berlin, Germany. Phone: 49 30 8412 2233. Fax: 49 30 8412 2953. E-mail: r.helmuth{at}bgvv.de.

Journal of Clinical Microbiology, September 2002, p. 3184-3191, Vol. 40, No. 9
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.9.3184-3191.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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