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Journal of Clinical Microbiology, January 2003, p. 435-438, Vol. 41, No. 1
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.1.435-438.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Determination of Immunoglobulin A against Gardnerella vaginalis Hemolysin, Sialidase, and Prolidase Activities in Vaginal Fluid: Implications for Adverse Pregnancy Outcomes

Sabina Cauci,1* Poul Thorsen,2 Diana E. Schendel,3 Annie Bremmelgaard,4 Franco Quadrifoglio,1 and Secondo Guaschino5

Department of Biomedical Sciences and Technologies, School of Medicine, University of Udine, Udine,1 Obstetric and Gynecologic Unit, Department of Reproductive and Development Sciences, IRCCS Burlo Garofolo Hospital, University of Trieste, Trieste, Italy,5 Department of Epidemiology and Social Medicine and Danish Epidemiology Science Centre, Aarhus University, Aarhus,2 Department of Clinical Microbiology, Frederiksberg Hospital, Copenhagen, Denmark,4 National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia3

Received 22 July 2002/ Returned for modification 18 September 2002/ Accepted 24 October 2002

A nested case-control study of low birth weight and preterm delivery was performed with singleton women. Immunoglobulin A (IgA) against the Gardnerella vaginalis hemolysin (anti-Gvh IgA) and sialidase and prolidase activities were determined in vaginal fluid at 17 weeks of gestation. Sialidase positivity and bacterial vaginosis with high prolidase activity were associated with 2- and 11-fold increased risks for low birth weight, respectively. No woman with bacterial vaginosis plus a strong anti-Gvh IgA response had an adverse outcome.

* Corresponding author. Mailing address: Dipartimento di Scienze e Tecnologie Biomediche, Piazzale Kolbe 4, 33100 Udine, Italy. Phone: 39 0432 494312. Fax: 39 0432 494301. E-mail: scauci{at}mail.dstb.uniud.it.

Journal of Clinical Microbiology, January 2003, p. 435-438, Vol. 41, No. 1
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.1.435-438.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.





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