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Journal of Clinical Microbiology, January 2003, p. 447-448, Vol. 41, No. 1
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.1.447-448.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Accuracy of a Commercial Enzyme-Linked Immunosorbent Assay for CagA in Patients from Brazil with and without Gastric Carcinoma

Andreia Maria Camargos Rocha, Gifone Aguiar Rocha, Adriana Santos, Celso Affonso de Oliveira, and Dulciene Maria Magalhães Queiroz*

Laboratory of Research in Bacteriology, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil

Received 30 April 2002/ Returned for modification 3 August 2002/ Accepted 17 September 2002

We validated a commercial enzyme-linked immunosorbent assay for the detection of anti-CagA antibodies in Brazilian patients with Helicobacter pylori infection. The test presented high sensitivity (97.4%) and specificity (88.9%) when employed in patients without gastric carcinoma. However, in gastric carcinoma patients, the test was neither sensitive nor specific enough to detect cagA-positive H. pylori infection.

* Corresponding author. Mailing address: Faculdade de Medicina, Av. Alfredo Balena, 190/4026, 30130-100 Belo Horizonte, Brazil. Phone and fax: 00 55 31 32742767. E-mail: dqueiroz{at}medicina.ufmg.br.

Journal of Clinical Microbiology, January 2003, p. 447-448, Vol. 41, No. 1
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.1.447-448.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.





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