This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Alarcón, T.
Right arrow Articles by López-Brea, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Alarcón, T.
Right arrow Articles by López-Brea, M.

 Previous Article  |  Next Article 

Journal of Clinical Microbiology, January 2003, p. 486-499, Vol. 41, No. 1
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.1.486-488.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Clarithromycin Resistance among Helicobacter pylori Strains Isolated from Children: Prevalence and Study of Mechanism of Resistance by PCR-Restriction Fragment Length Polymorphism Analysis

Teresa Alarcón,1* Alba E. Vega,1,2 Diego Domingo,1 Maria Josefa Martínez,3 and Manuel López-Brea1

Department of Microbiology, Hospital Universitario de la Princesa,1 Gastroenterology Unit, Hospital del Niño Jesus, Madrid, Spain,3 University of San Luis, San Luis, Argentina2

Received 9 May 2002/ Returned for modification 18 June 2002/ Accepted 18 October 2002

Clarithromycin and metronidazole resistance was 29.1 and 23.9%, respectively, in 96 Helicobacter pylori strains obtained from pediatric patients. No resistance to amoxicillin was observed. Resistance according to patients' ages to clarithromycin and metronidazole was 45.4 and 18.2% in 22 patients from 4 to 8 years old, 30.2 and 20.7% in 53 patients from 9 to 13 years old, and 9.5 and 38.1% in 21 patients from 14 to 18 years old, respectively. The A2143G mutation was the most prevalent (82.1%) among clarithromycin-resistant strains.

* Corresponding author. Mailing address: Department of Microbiology, Hospital Universitario de la Princesa, Diego de León 62, 28006 Madrid, Spain. Phone and fax: 34 91 5202403. E-mail: talarcon{at}helicobacterspain.com.

Journal of Clinical Microbiology, January 2003, p. 486-499, Vol. 41, No. 1
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.1.486-488.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Alvarez, A., Moncayo, J. I., Santacruz, J. J., Santacoloma, M., Corredor, L. F., Reinosa, E. (2009). Antimicrobial Susceptibility and Mutations Involved in Clarithromycin Resistance in Helicobacter pylori Isolates from Patients in the Western Central Region of Colombia. Antimicrob. Agents Chemother. 53: 4022-4024 [Abstract] [Full Text]  
  • Noguchi, N., Rimbara, E., Kato, A., Tanaka, A., Tokunaga, K., Kawai, T., Takahashi, S., Sasatsu, M. (2007). Detection of mixed clarithromycin-resistant and -susceptible Helicobacter pylori using nested PCR and direct sequencing of DNA extracted from faeces. J Med Microbiol 56: 1174-1180 [Abstract] [Full Text]  
  • Koletzko, S, Richy, F, Bontems, P, Crone, J, Kalach, N, Monteiro, M L, Gottrand, F, Celinska-Cedro, D, Roma-Giannikou, E, Orderda, G, Kolacek, S, Urruzuno, P, Martinez-Gomez, M J, Casswall, T, Ashorn, M, Bodanszky, H, Megraud, F, on behalf of the European Paediatric Task Force on, (2006). Prospective multicentre study on antibiotic resistance of Helicobacter pylori strains obtained from children living in Europe. Gut 55: 1711-1716 [Abstract] [Full Text]  
  • Megraud, F (2004). H pylori antibiotic resistance: prevalence, importance, and advances in testing. Gut 53: 1374-1384 [Full Text]  
  • Fontana, C., Favaro, M., Pietroiusti, A., Pistoia, E. S., Galante, A., Favalli, C. (2003). Detection of Clarithromycin-Resistant Helicobacter pylori in Stool Samples. J. Clin. Microbiol. 41: 3636-3640 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»