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Journal of Clinical Microbiology, October 2003, p. 4817-4819, Vol. 41, No. 10
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.10.4817-4819.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Comparison of In Vitro Activities of 17 Antifungal Drugs against a Panel of 20 Dermatophytes by Using a Microdilution Assay

Bertrand Favre,{dagger} Bettina Hofbauer, Kwang-Soo Hildering,{ddagger} and Neil S. Ryder3*

Novartis Research Institute, Vienna, Austria

Received 11 February 2003/ Returned for modification 30 April 2003/ Accepted 29 July 2003

The in vitro activities of 17 antifungal drugs against a panel of 20 dermatophytes comprising 6 different species were determined using a microdilution assay according to the NCCLS M38-P method with some modifications. Terbinafine was the most potent systemic drug while tolnaftate and amorolfine were the most active topical agents.

* Corresponding author. Mailing address: Infectious Diseases Biology, Room 4210, Novartis Institutes for Biomedical Research, Inc., 100 Technology Square, Cambridge, MA 02139. Phone: (617) 871-3143. Fax: (617) 871-7047. E-mail: neil.ryder{at}pharma.novartis.com.

{dagger} Present address: Department of Dermatology, University Hospital CHUV, Lausanne, Switzerland.

{ddagger} Present address: Igeneon, Vienna, Austria.

§ Present address: Novartis Institutes for Biomedical Research, Inc., Cambridge, MA 02139.

Journal of Clinical Microbiology, October 2003, p. 4817-4819, Vol. 41, No. 10
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.10.4817-4819.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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