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Journal of Clinical Microbiology, October 2003, p. 4836-4838, Vol. 41, No. 10
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.10.4836-4838.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Dissemination of Extended-Spectrum ß-Lactamase-Producing Enterobacteriaceae in Pediatric Intensive Care Units

Tsu-Lan Wu,1 Ju-Hsin Chia,1 Lin-Hui Su,1 An-Jing Kuo,1 Chishih Chu,2 and Cheng-Hsun Chiu2*

Department of Clinical Pathology, Chang Gung Memorial Hospital,1 Department of Pediatrics, Chang Gung Children's Hospital, Taoyuan, Taiwan2

Received 14 May 2003/ Returned for modification 4 June 2003/ Accepted 21 July 2003

To study the growing trend of extended-spectrum ß-lactamase (ESBL)-producing Enterobacteriaceae in pediatric intensive care units (PICUs), 88 nonrepetitive ESBL-producing isolates were prospectively collected and analyzed by molecular methods during a 16-month period. The emergence and dissemination of ESBL-producing Enterobacteriaceae in PICUs are the consequence of the clonal dissemination of a few epidemic strains along with the horizontal transmission of resistance gene-carrying plasmids among bacterial organisms.

* Corresponding author. Mailing address: Department of Pediatrics, Chang Gung Children's Hospital, 5 Fu-Hsin St., Kweishan 333, Taoyuan, Taiwan. Phone: 886 3 3281200. Fax: 886 3 3288957. E-mail: chchiu{at}adm.cgmh.org.tw.

Journal of Clinical Microbiology, October 2003, p. 4836-4838, Vol. 41, No. 10
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.10.4836-4838.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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