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Journal of Clinical Microbiology, October 2003, p. 4848-4851, Vol. 41, No. 10
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.10.4848-4851.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Detection of Differences in the Nucleotide and Amino Acid Sequences of Diphtheria Toxin from Corynebacterium diphtheriae and Corynebacterium ulcerans Causing Extrapharyngeal Infections

Andreas Sing,1* Michael Hogardt,2 Suse Bierschenk,2 and Jürgen Heesemann1

National Consiliary Laboratory on Diphtheria,1 Max von Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie, 80336 Munich, Germany2

Received 26 March 2003/ Returned for modification 13 May 2003/ Accepted 20 July 2003

While Corynebacterium ulcerans can mimic classical diphtheria, extrapharyngeal infections are extremely rare. Sequencing of the diphtheria toxin (DT)-encoding tox gene of two C. ulcerans isolates from extrapharyngeal infections revealed differences from C. diphtheriae DT sequences, mainly in the translocation and receptor-binding domains. C. ulcerans supernatants were much less potent than supernatant from C. diphtheriae. A C. ulcerans DT-specific PCR is described below.

* Corresponding author. Mailing address: Max von Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie, Pettenkoferstraße 9a, 80336 München, Germany. Phone: 49-89-5160-5426. Fax: 49-89-5160-5223. E-mail: sing{at}m3401.mpk.med.uni-muenchen.de.

Journal of Clinical Microbiology, October 2003, p. 4848-4851, Vol. 41, No. 10
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.10.4848-4851.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Schuhegger, R., Lindermayer, M., Kugler, R., Heesemann, J., Busch, U., Sing, A. (2008). Detection of Toxigenic Corynebacterium diphtheriae and Corynebacterium ulcerans Strains by a Novel Real-Time PCR. J. Clin. Microbiol. 46: 2822-2823 [Full Text]  
  • Cassiday, P. K., Pawloski, L. C., Tiwari, T., Sanden, G. N., Wilkins, P. P. (2008). Analysis of Toxigenic Corynebacterium ulcerans Strains Revealing Potential for False-Negative Real-Time PCR Results. J. Clin. Microbiol. 46: 331-333 [Abstract] [Full Text]  
  • Lartigue, M.-F., Monnet, X., Le Fleche, A., Grimont, P. A. D., Benet, J.-J., Durrbach, A., Fabre, M., Nordmann, P. (2005). Corynebacterium ulcerans in an Immunocompromised Patient with Diphtheria and Her Dog. J. Clin. Microbiol. 43: 999-1001 [Abstract] [Full Text]  


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