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Journal of Clinical Microbiology, November 2003, p. 5212-5214, Vol. 41, No. 11
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.11.5212-5214.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Performance of the Focus and Kalon Enzyme-Linked Immunosorbent Assays for Antibodies to Herpes Simplex Virus Type 2 Glycoprotein G in Culture-Documented Cases of Genital Herpes

University of Washington Departments of Laboratory Medicine,¹ Medicine,³ Children's Hospital and Regional Medical Center, Seattle, Washington²

Received 23 December 2002/ Returned for modification 22 June 2003/ Accepted 11 September 2003

Glycoprotein G-based herpes simplex virus type 2 (HSV-2) enzyme-linked immunosorbent assays from Focus and Kalon were performed with specimens from 118 patients with culture-documented genital herpes episodes, and their results were compared. Sensitivity was 52% by Kalon and 86% by Focus for first HSV-2 episodes and 100% (for each of the two tests) for recurrent HSV-2. Median times to seroconversion were 120 days by the Kalon assay, 21 days by the Focus assay, and 68 days by Western blotting assay. Values for specificity were 100% (Kalon) and 93% (Focus).

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